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. 2019 Jan 4;16(1):122. doi: 10.3390/ijerph16010122

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Doxycycline-induced expression of constitutively activated B-Raf proto-oncogene, serine/threonine kinase (BRAF) in vivo regulates several mRNAs included in the ECGS and genes evidenced by the network analyses. RNA was prepared from thyroid of mice expressing a mutated B-Raf oncogene only when treated with doxycycline (BRAFV600E + Dox) and from untreated animals (Ctrl). After 1 week of exposure, mice developed thyroid cancers and were sacrificed. (A) ECGS mRNA levels, determined by RT-qPCR in control and treated animals. (B) p65 and IκBα mRNAs were determined by RT-qPCR in the same samples as in A. Data are reported as the average and standard deviation of Abl-normalized mRNA levels of 5 animals. Mean and standard deviation is reported. (Dmbt1 p-value = 0.030; Znf703 p = 0.015; Zfp36l2 p = 0.025).