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. 2019 Jan 4;16(1):122. doi: 10.3390/ijerph16010122

Table 1.

Ingenuity Pathway Analysis (IPA) biofunctions deregulated in chlorpyrifos (CPF) treated PCCL3. Biofunctions containing at least two genes are reported with indication of genes identifying each category. In bold are reported the genes included in the endodermal carcinogenic gene-network (ECGN).

Categories Diseases or Functions Annotation Corrected p-Value Genes
Cell Cycle Entry into G2 phase 2.86 × 10−2 EGR1, RUNX2
Cellular Growth and Proliferation, Embryonic Development Formation of embryonic cells 2.86 × 10−2 GNAO1, RUNX2
Gene Expression Transcription of DNA 2.86 × 10−2 BEX1, EGR1, FZD5, GTF3C6, HEXIM2, HMGA1, RUNX2, TARBP1, ZFP36L2, ZNF628, ZNF703
Cancer, Organismal Injury and Abnormalities Epithelial cancer 2.86 × 10−2 BEX1, C9orf172, CDKL4, CHD9, CHSY3, CLEC16A, CPEB2, CTNNAL1, DDIT4, DENND4C, DMBT1, EGR1, FZD5, GNAO1, GTF3C6, HEXIM2, HMGA1, INPP5J, KIAA1217, NWD2, PRR12, RUNX2, SEMA6A, SLC25A36, SMG7, SUSD6, TARBP1, WDR76, ZFP36L2, ZNF628, ZNF703
Cellular Development, Hematological System Development and Function, Hematopoiesis Erythropoiesis of cells 2.86 × 10−2 EGR1, HMGA1
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease Mammary tumor 2.86 × 10−2 BEX1, CPEB2, CTNNAL1, DDIT4, EGR1, GNAO1, INPP5J, RUNX2, SUSD6, ZFP36L2, ZNF703
Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development Differentiation of T-lymphocytes 2.86 × 10−2 EGR1, FZD5, HMGA1, RUNX2, ZFP36L2
Cellular Development, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development Development of lymphocytes EGR1, Fus, FZD5, HMGA1, RUNX2, ZFP36L2
Endocrine System Development and Function, Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry Secretion of aldosterone EGR1, HMGA1