Table 3.
Concentrations (µg/g creatinine) of metabolites for the chemical exposure (SPMA and cotinine) and the oxidation biomarkers (8-oxoGua, 8-oxodGuo and 8-oxoGuo) in Group 1, before and after shift, stratified by smoking habit.
| Before Shift | ||||||||
| Analyte | Smokers (n = 14) | Non-Smokers (n = 15) | ||||||
| Mean (SD) | Percentile | Mean (SD) | Percentile | |||||
| 5th | 50th | 95th | 5th | 50th | 95th | |||
| SPMA | 13.97 (12.93) |
2.57 | 8.52 | 37.42 | 14.45 (17.72) |
0.58 | 5.58 | 49.57 |
| Cotinine | 1619.97 (1057.26) |
380.58 | 1362.20 * | 3203.78 | 28.71 (28.14) |
5.14 | 19.62 * | 87.36 |
| 8-oxoGua | 140.71 (231.25) |
2.20 | 44.66 | 610.10 | 81.39 (74.11) |
13.10 | 55.94 | 231.54 |
| 8-oxodGuo | 15.70 (6.12) |
7.62 | 15.87 | 24.89 | 16.47 (5.87) |
7.37 | 17.12 | 24.75 |
| 8-oxoGuo | 33.32 (17.83) |
9.80 | 30.98 | 62.12 | 32.35 (10.03) |
20.53 | 28.86 | 52.46 |
| After Shift | ||||||||
| Analyte | Smokers (n = 14) | Non-Smokers (n = 15) | ||||||
| Mean (SD) | Percentile | Mean (SD) | Percentile | |||||
| 5th | 50th | 95th | 5th | 50th | 95th | |||
| SPMA | 14.39 (11.00) |
2.42 | 11.36 | 34.76 | 9.89 (9.29) |
0.89 | 6.50 | 24.73 |
| Cotinine | 1404.18 (908.34) |
514.09 | 1353.53 * | 2631.33 | 17.64 (16.90) |
3.20 | 11.27 * | 47.37 |
| 8-oxoGua | 72.95 (78.89) |
1.44 | 48.96 | 207.02 | 40.03 (41.88) |
2.45 | 21.44 | 120.00 |
| 8-oxodGuo | 17.46 (11.54) |
7.78 | 14.46 | 36.49 | 12.99 (5.62) |
5.05 | 13.72 | 21.06 |
| 8-oxoGuo | 31.26 (16.59) |
8.68 | 27.01 | 61.15 | 27.19 (15.13) |
7.55 | 26.97 | 49.53 |
* smokers vs. non-smokers (Mann-Whitney test).