Fig. 2.

Hit 1/Hit 2 (H1/H2) induced chronic inflammation and leptin dysregulation in visceral adipose tissue. Fold change in the mRNA expression of (a) TNF-receptor 1 (TNF-R1), (b) TNF-R2, and (c) leptin in retroperitoneal adipose tissue was decreased by prenatal dexamethasone exposure and increased by postnatal high-fat (HF) diet. Results were analyzed using two-way ANOVA (prenatal dexamethasone exposure × postnatal HF diet). All values are presented as the mean ± standard error (n = 8). *P < 0.05. VEH, normal diet; DEX, prenatal dexamethasone exposure; VHF, postnatal HF diet; DHF, prenatal dexamethasone plus postnatal HF diet