Table 1.
Body weight/ adipose tissue weight, biochemistry and other biomarkers
| VEH | DEX | VHF | DHF | H1 | H2 | H1 × H2 | |
|---|---|---|---|---|---|---|---|
| Weight (g) | 666.33 ± 18.70 | 668.00 ± 29.50 | 763.33 ± 45.42 | 942.17 ± 61.84*#† | p = 0.045 | p < 0.001 | p = 0.048 |
| Retroperitoneal fat (g) | 13.96 ± 1.77 | 13.17 ± 1.36 | 28.95 ± 4.53* | 48.50 ± 4.47*#† | p = 0.012 | p < 0.001 | p = 0.007 |
| Subcutaneous fat (g) | 26.78 ± 2.65 | 30.72 ± 3.27 | 56.42 ± 7.36 | 79.25 ± 9.91 | NS | p < 0.001 | NS |
| Mesenteric fat (g) | 5.76 ± 0.93 | 5.58 ± 0.68 | 9.17 ± 1.54 | 13.91 ± 2.12 | NS | p = 0.001 | NS |
| Epididymal fat (g) | 7.35 ± 0.41 | 8.05 ± 0.17 | 18.05 ± 1.46 | 21.42 ± 1.65 | NS | p < 0.001 | NS |
| AST (U/L) | 128.25 ± 45.53 | 97.40 ± 9.37 | 146.33 ± 11.32 | 248.50 ± 28.92#† | NS | p = 0.004 | p = 0.018 |
| ALT (U/L) | 85.75 ± 52.12 | 44.80 ± 2.46 | 78.17 ± 11.58 | 156.67 ± 9.65#† | NS | p = 0.026 | p = 0.012 |
| T-Cholesterol (mg/dL) | 88.50 ± 10.74 | 107.40 ± 17.72 | 81.17 ± 5.34 | 63.50 ± 5.49 | NS | p = 0.025 | NS |
| Triglyceride (mg/dL) | 104.75 ± 5.20 | 136.60 ± 30.76 | 54.00 ± 6.67 | 57.67 ± 8.64 | NS | p = 0.001 | NS |
| ALK-P (U/L) | 65.50 ± 11.30 | 55.80 ± 3.73 | 49.00 ± 4.68 | 62.67 ± 7.54 | NS | NS | NS |
| Leptin (ng/ml) | 2.66 ± 0.30 | 2.58 ± 0.99 | 4.62 ± 0.48 | 4.39 ± 0.33 | NS | p < 0.001 | NS |
| TNFα (pg/ml) | 7.81 ± 0.48 | 8.68 ± 0.18 | 11.29 ± 0.14 | 11.36 ± 0.54 | NS | p < 0.001 | NS |
| VEGF (pg/ml) | 15.21 ± 0.24 | 15.51 ± 0.29 | 16.53 ± 0.23 | 16.47 ± 0.28 | NS | p < 0.001 | NS |
AST aspartate transaminase, ALT alanine aminotransferase, ALK-P Alkaline phosphatase, VEGF vascular endothelial growth factor, VEH prenatal saline vehicle /postnatal normal diet group, DEX prenatal dexamethasone exposure /postnatal normal diet group, VHF prenatal saline vehicle /postnatal high fat diet group, DHF prenatal dexamethasone exposure /postnatal high-fat diet group. * as compared with VEH, p < 0.05; # as compared with DEX, p < 0.05; † as compared with VHF, p < 0.05