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. 2019 Jan 18;18:17. doi: 10.1186/s12944-019-0966-y

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — A non-linear relationship with threshold effect between plasma HDL-C concentrations and EBB-induced bleeding risk in the smooth curve fitting after adjusting the potential confounding factors (sex, age, smoking, location of lesion, histological type, stage of cancer, triglyceride, apolipoprotein E, PT, APTT, neutrophils and CRP) is shown in the figure. Dotted lines represent the upper and lower 95% confidence intervals. EBB = endobronchial biopsy; HDL-C = high density lipoprotein cholesterol; PT = prothrombin time; APTT = activated partial thromboplastin time; CRP = C-reactive protein