Table 2.
Univariate analysis of possible influencing factors of the risk of EBB-induced bleeding
| Variables | EBB-induced Bleeding | |
|---|---|---|
| OR (95% CI) | P value | |
| Age (year) | 1.01 (0.99, 1.03) | 0.2029 |
| Sex | ||
| Female | Ref. | |
| Man | 1.33 (0.89, 1.98) | 0.1609 |
| Smoking | ||
| No | Ref. | |
| Yes | 1.45 (1.03, 2.04) | 0.0337 |
| Location of lesion | ||
| Central airway | Ref. | |
| Peripheral bronchi | 0.32 (0.20, 0.51) | < 0.0001 |
| Stage | ||
| Early | Ref. | |
| Advanced | 1.87 (1.35, 2.60) | 0.0002 |
| Histological type | ||
| Adenocarcinoma | Ref. | |
| Squamous cell carcinoma | 2.63 (1.73, 4.01) | < 0.0001 |
| SCLC | 2.14 (1.27, 3.61) | 0.0043 |
| Others | 2.20 (1.00, 4.82) | 0.0488 |
| COPD | ||
| No | Ref. | |
| Yes | 1.05 (0.55, 2.01) | 0.8727 |
| Hypertension | ||
| No | Ref. | |
| Yes | 1.11 (0.76, 1.61) | 0.5995 |
| Diabetes | ||
| No | Ref. | |
| Yes | 0.89 (0.42, 1.88) | 0.7575 |
| CHD | ||
| No | Ref. | |
| Yes | 1.14 (0.46, 2.84) | 0.7736 |
| Triglyceride (mmol/L) | 0.80 (0.62, 1.04) | 0.1018 |
| TC (mmol/L) | 0.93 (0.78, 1.11) | 0.4113 |
| HDL-C (mmol/L) | 0.56 (0.34, 0.94) | 0.0270 |
| LDL-C (mmol/L) | 0.89 (0.71, 1.11) | 0.3031 |
| Apo E (mg/dL) | 0.91 (0.82, 1.02) | 0.1153 |
| Apo B (g/L) | 0.80 (0.45, 1.42) | 0.4421 |
| Homocysteine (μmol/L) | 1.00 (0.98, 1.02) | 0.8840 |
| WBC (×109/L) | 1.03 (0.98, 1.08) | 0.2477 |
| Neutrophils (×109/L) | 1.04 (0.99, 1.10) | 0.0937 |
| Hemoglobin (g/L) | 1.00 (0.99, 1.01) | 0.4135 |
| Platelets (×109/L) | 1.00 (1.00, 1.00) | 0.2392 |
| CRP (mg/L) | 1.01 (1.00, 1.01) | 0.0173 |
| PT (S) | 0.93 (0.84, 1.02) | 0.1220 |
| APTT (S) | 0.96 (0.94, 0.99) | 0.0180 |
| ALT (IU/L) | 1.00 (0.99, 1.01) | 0.8181 |
| AST (IU/L) | 1.00 (0.99, 1.01) | 0.9365 |
EBB endobronchial biopsy; SCLC small-cell lung carcinoma; COPD Chronic obstructive pulmonary disease; CHD coronary heart disease; TC total cholesterol; HDL-C high density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; Apo, apolipoprotein; WBC white blood cell; CRP C-reactive protein; PT prothrombin time; APTT activated partial thromboplastin time; ALT alanine aminotransferase; AST aspartate aminotransferase