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. 2019 Jan 18;19:23. doi: 10.1186/s12886-018-1017-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — SQ22536 did not suppress the quantity of TGF-β₂ protein induced by ATRA in the supernatants of D407 cells. TGF-β₂ protein levels in conditioned media were measured by ELISA and normalized to cell counts (1 × 10⁶). There was no significant difference in the secretion of TGF-β₂ of the ATRA-treated group and SQ22536 (5–40 μM) + ATRA-treated group (p > 0.05). Data are represented as the mean ± SEM. Statistical comparisons were performed with one-way ANOVA. *Significance versus control group (p < 0.001; n = 3 per treatment). ^#Significance versus ATRA-treat group (10 μM) (p < 0.001; n = 3 per treatment)