Table 4.
Association between number of malaria episodes and antibody level in 18 months old children
| Antigen tested/parasite isolate | Unadjusted coefficient (95% CI) | p valuea | Adjusted coefficient (95% CI) | p valueb |
|---|---|---|---|---|
| MSP1 19 kDc | 1.85 (1.43, 2.41) | < 0.0001 | 1.83 (1.41, 2.37) | < 0.0001 |
| MSP2d | 1.28 (1.00, 1.63) | 0.047 | 1.26 (0.99, 1.61) | 0.057 |
| EBA175e | 0.92 (0.75, 1.11) | 0.399 | 0.91 (0.76, 1.10) | 0.378 |
| Rh2A9f | 1.14 (0.98, 1.33) | 0.074 | 1.14 (0.98, 1.33) | 0.082 |
| Schizont | 1.52 (1.21, 1.91) | < 0.0001 | 1.50 (1.19, 1.87) | < 0.0001 |
| E8Bg | 1.06 (0.75, 1.50) | 0.719 | 1.03 (0.73, 1.46) | 0.826 |
| R29h | 1.33 (0.79, 2.24) | 0.267 | 1.39 (0.81, 2.40) | 0.222 |
| 3D7h | 1.16 (0.79, 1.72) | 0.434 | 1.13 (0.77, 1.67) | 0.508 |
Significant p value in italic format
ap-value derived from linear regression of antibody levels and reported as coefficient and 95% confidence intervals (CI)
bp-value calculated using multivariate linear regression of antibody levels reporting coefficient and 95% confidence intervals (CI) while adjusting for duration of gestation, HIV infection, gender of the child, maternal anaemia
cMerozoite surface protein 1
dMerozoite surface protein 2
eErythrocyte binding antigen 175
fReticulocyte binding protein homologue 2A
gVariant surface antigen antibody responses