Table 4.
Side effects of first generation antipsychotics and management practices at Amanuel Specialized Mental Hospital
| Variable category | Frequency(%) | |
|---|---|---|
| Side effect developed | Yes | 293 (97.7) |
| No | 7 (2.3) | |
| Management of side effects | No side effect management | 84 (28.0) |
| Dose reduction of antipsychotics | 51 (17.0) | |
| Trihexyphenidyl given | 163 (54.3) | |
| Other interventions | 2 (0.7) | |
| Response to side effect management | Responded | 20 (6.7) |
| No response | 196 (65.3) | |
| Unknown response | 84 (28.0) | |
| Side effect managed in accordance with APA guideline | Yes | 38 (17.6) |
| No | 178 (82.4) | |
| Severity of side effects based on GASS | Mild side effects | 165 (55.0) |
| Moderate side effects | 127 (42.3) | |
| Severe side effects | 8 (2.7) | |
| Type of side effect | Cardiovascular | 169 (56.3) |
| Sedation and CNS | 149 (49.6) | |
| Extrapyramidal | 114 (38.0) | |
| Gastrointestinal | 95 (31.7) | |
| Anti-cholinergic | 73 (24.3) | |
| Diabetes mellitus | 73 (24.3) | |
| Genitourinary | 46 (15.3) | |
| Weight gain | 61 (20.3) | |
| Hyperprolactinemia | 41 (13.7) | |
APA American Psychiatric Association