Table 5.
The probability of first generation antipsychotics induced adverse drug reactions in patients with schizophrenia at Amanuel Specialized Mental Hospital
| Category of ADR; n(%) | Type of ADR (Frequency) | FDAs associated with the ADR |
|---|---|---|
| Definite reaction 67 (22.3%) | Dizziness (28) | Chlorpromazine |
| Irregularity in heart beat (11) | Chlorpromazine | |
| Sedation (14) | Chlorpromazine | |
| EPS (14) | Fluphenazine depot (11) + Haloperidol (8) | |
| Probable reaction 145 (48.3) | EPS (44) | Haloperidol(23) + fluphenazine depot(21) |
| Sedation (15) | Chlorpromazine(11) + thioridazine(4) | |
| Constipation (9) | Fluphenazine depot | |
| Dizziness (46) | Chlorpromazine(23) + Haloperidol(23) | |
| Sexual dysfunction (3) | Chlorpromazine(2) + Haloperidol(1) | |
| Irregularity in heart beat (37) | Chlorpromazine(20) + fluphenazine depot(17) | |
| Possible reaction 75 (25.0) | Irregularity in heart beat (31) | Chlorpromazine (23) + Haloperidol (8) |
| Dizziness (12) | Chlorpromazine | |
| Dry mouth (10) | Chlorpromazine | |
| Insomnia (9) | Haloperidol | |
| Menstrual abnormality (5) | Fluphenazine depot | |
| Drooling (11) | Fluphenazine depot |