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. 2019 Jan 18;38:25. doi: 10.1186/s13046-019-1033-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — BMI1 constitutes a potential interaction partner in the ZDHHC18/ZDHHC23 protein interaction network in proneural and mesenchymal glioma stem cells (GSCs). a, b Lysates from proneural GSCs (PN12) and mesenchymal GSCs (MES23) were subjected to immunoprecipitation using anti-ZDHHC18 and anti-ZDHHC23 antibodies, respectively, and then (a) immunoblotted with anti-ZDHHC18 and anti-ZDHHC23 antibodies, or (b) the IP-protein complex was subjected to LC/MS-MS analysis. Venn diagrams showing the overlaps between specific peaks of the various IP-protein complexes. c Protein–protein interaction networks indicated by STRING software showing the overlapping peaks in both the proneural and mesenchymal GSCs after immunoprecipitation with anti-ZDHHC18 and anti-ZDHHC23 antibodies, respectively. The shared regions mostly converged on 31 protein targets, generally associated with retrograde transport, nuclear-transcribed mRNA catabolic process, cellular lipid, and glucose metabolic processes, H2A monoubiquitination, hypoxia microenvironment, and glioma development