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. 2019 Jan 18;7:14. doi: 10.1186/s40425-019-0497-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — High frequencies of tumor-infiltrating Foxp3+ Tbet+ Tregs correlate with survival in OPSCC patients. Kaplan-Meier survival curves showing the outcome of 38 tested HPV16-positive OPSCC patients with high (above the median) and low (below the median) numbers of total CD8–Foxp3+, CD8–Foxp3+Tbet+ and CD8–Foxp3+Tbet– (top to bottom; left), and CD8–Foxp3–Tbet+, total T cell infiltrate (without CD8–Foxp3+Tbet+ cells) and total Tbet+ T cells/mm2 (top to bottom; right). T cell subsets were determined by IHC staining. Statistical significance of the survival distribution was analyzed by log-rank testing and differences were considered significant when p < 0.05, as indicated with an asterisk (*p < 0.05, **p < 0.01, *** p < 0.001 and **** p < 0.0001)