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. 2019 Jan 18;21:28. doi: 10.1186/s13075-019-1815-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Autoantibody levels change following treatment decisions.

Change in autoantibody levels (calculated by GEE) following treatment decision at 8 months, within patients that were positive for that autoantibody at least once over the first year. Depicted regression coefficients (β in aU/mL, with 95% CIs) are of the predictor time from a GEE model stratified for the treatment decision, and thus indicate autoantibody level changes between 8 and 12 months for that treatment decision group. Coefficients were normalized for comparison purposes by dividing by the maximum arbitrary units per milliliter of the ELISA range of each autoantibody. Models were adjusted for age, gender, smoking status, and disease duration. Bold typeface of p values calculated by GEE (interaction term treatment*time) indicates significance after Holmes-Bonferroni correction for multiple testing (14 tests)