Table 1: List of selected simulation parameters.

STI, sexually transmitted infection; PrEP, pre-exposure prophylaxis for HIV.

Model Parameters	Value/[Range]1	Reference
HIV disease state duration
Acute infection	[6, 9] weeks	1S–3S
Chronic infection	[8, 10] years	1S,4S
Late infection2	[1, 3] years	1S,2S,4S
Time from ART initiation to full viral suppression	[3, 6] months	5S
Time from ART discontinuation to pre-ART CD4 nadir3	[3, 9] months	6S–9S
HIV mortality rate, acute and chronic HIV, no ART	5 per 1000 person years	10S–12S
Reduction in HIV mortality due to ART	0.58 * Mortality rate in chronic state
Probability of ART discontinuation	(20%,50%,90%) by the end of (1st,2nd, 8th) year, 50% per year afterward4	13S
Average viral load (log10 copies/mL)
Acute, no ART	6.5
Chronic, no ART	4.5
Late, no ART	5
On ART, partially suppressed	3.5
On ART, fully suppressed	1.5
Infectiousness per sexual contact	2.45(log(VL)-4.5)	1S
Annual number STI clinic visits among MSM	966	1S
PrEP reassessment period	3 months	14S
PrEP uptake	60% [0–100%]
PrEP adherence5	60% [0–100%]

¹Values generated via uniform distributions over the specified range unless stated otherwise

²Duration reflects the mortality rate due to late HIV disease

³Infectiousness assumed equal to that of the chronic state

⁴Values adjusted via a simulation coefficient (p=0.7) for calibration to Baltimore data

⁵PrEP is 100% effective if adhered to