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. 2019 Jan 15;12:587–598. doi: 10.2147/OTT.S187426

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© 2019 Tang et al. This work is published and licensed by Dove Medical Press Limited

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Scutellarin-enhanced sensitivity to cisplatin in glioma cells.

Notes: The cisplatin-resistant U87 and U251 cells were established. (A, B) Cell viability of cisplatin-resistant U87 and cisplatin-resistant U251 cells to cisplatin after scutellarin pretreatment or vehicle treatment. (C, D) Cell apoptosis of cisplatin-resistant U87 and U251 cells after scutellarin pretreatment or vehicle treatment. (E) Western blot analysis of cleaved caspase-3, p53, Bax, Bcl-2, p-ERK, and ERK levels in U87/DDP cells treated by cisplatin, or scutellarin, or the combination. (F) Western blot analysis of LC3I and LC3II levels in U87/DDP cells treated by cisplatin, or scutellarin, or the combination. ^*P<0.05 vs control. Data are represented as mean ± SD of three independent experiments.