Table 1.
Available alert actions by site and DGI
| Site | Gene | Drug | Accept with No Update | Accept with Update | Explicit Cancel | Implicit Cancel | View Educational Materials | Override with Reason | Override with No Reason | Other |
|---|---|---|---|---|---|---|---|---|---|---|
| Cincinnati Children’s | CYP2D6 | codeine | X | X | ||||||
| oxycodone | ||||||||||
| hydrocodone | ||||||||||
| tramadol | ||||||||||
| Marshfield Clinic | CYP2C19 | clopidogrel | X | X | X | |||||
| SLCO1B1 | simvastatin | X | X | X | ||||||
| CYP2C9, VKORC1 | warfarin | X | X | X | ||||||
| Mayo Clinic | CYP2C19 | clopidogrel | X | X | X | |||||
| SLCO1B1 | simvastatin | X | X | X | ||||||
| CYP2C9, VKORC1 | warfarin | X | X | X | ||||||
| Mt. Sinai | CYP2C19 | clopidogrel | X | X | X | X | X | X | X | |
| SLCO1B1 | simvastatin | X | X | X | X | X | X | X | ||
| CYP2C9, VKORC1 | warfarin | X | X | X | X | X | X | X | X | |
| Northwestern | CYP2C19 | clopidogrel | X | X | X | X | ||||
| SLCO1B1 | simvastatin | X | X | X | X | |||||
| CYP2C9, VKORC1 | warfarin | X | X | X | X | |||||
| Vanderbilt | CYP2C19 | clopidogrel | X | X | X | X | ||||
| CYP2C9, VKORC1 | warfarin | X | X |
Sites varied in the actions that they provided to users on PGx CDS alerts, which affected the Accept, Override, and Ignore rates found upon aggregation. Table includes only the 6 sites that submitted data for aggregation in Table 2.