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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Clin Cancer Res. 2018 Oct 15;25(2):629–640. doi: 10.1158/1078-0432.CCR-18-1033

Figure 5. SGK1 re-expression reduces lung metastases in an orthotopic xenograft model of CRC and is associated with poor differentiation and inferior prognosis in human CRCs.

Figure 5

A. Ex vivo analysis of luminescence from lung metastases of LS174T-SGK1 and parental cells, demonstrates only very small lesions in the former.

B. Lung metastasis burden after orthotopic delivery of LS174T-SGK1 is much lower than in parental cells.

C. Immunohistochemical detection of SGK1 in a human CRC tissue microarray shows significantly less expression in poorly differentiated CRCs (p<0.01).

D. Data from TCGA demonstrate that patients with the lowest expression of SGK1 have significantly poorer overall survival (p<0.001).