Table 1. Top dysregulated pathways in cell lines re-expressing SGK1 compared with parental controls.

The normalised enrichment core (NES) shows that SGK1 re-expressing cell lines have significantly less expression of gene sets such as Rb/E2F signalling, MYC targets and EMT, with increased expression of gene sets including differentiation, cell polarity and adhesion.

Gene Set	NES	p-value
Protein kinase cascade	1.34	0.004
Cell polarity	1.70	0.010
Regulation of cell differentiation	1.54	0.014
Cell substrate adhesion	1.45	0.031
Stress activated protein kinase signalling pathway	1.39	0.040
Cell matrix adhesion	1.43	0.044
Regulation of cell adhesion	1.47	0.047
Epithelial morphogenesis	-1.38	0.005
Epithelial-mesenchymal transition	-1.69	0.013
MYC targets	-2.61	<0.001
mTORC1 signalling	-2.61	<0.001
Rb/E2F signalling	-1.56	<0.001