Table 3.

HRs of Incident Ischemic Stroke, CHD, and the Composite Outcome Comparing 2 vs 0 or 1 APOL1 Risk Variants (Recessive Model)

	Events/Total N (%)	Crude, HR (95% CI)	Model 1, HR (95% CI)	Model 2, HR (95% CI)
Ischemic stroke*	331/9375 (3.5)	1.09 (0.80–1.49)	1.14 (0.83–1.57)	1.34 (0.85–2.14)
CHD†	323/8590 (3.8)	1.14 (0.82–1.60)	1.15 (0.82–1.62)	0.97 (0.63–1.50)
Composite events‡	500/7908 (6.4)	1.14 (0.89–1.46)	1.16 (0.90–1.49)	1.15 (0.82–1.61)

Model 1 adjusted for age, sex, smoking, hypertension, lipid-lowering medications and diabetes mellitus (events/N: stroke=322/9140; CHD=317/8381; composite=490/7719). Model 2 adjusted for variables in model 1 plus ancestry principal components (events/N: stroke=127/6324; CHD=221/5894; composite=273/5435). CHD indicates coronary heart disease; CI, confidence interval; and HR, hazard ratio.

^*Excludes prevalent stroke, hemorrhagic, and nonadjudicated strokes.

^†Excludes prevalent coronary heart disease.

^‡Excludes prevalent stroke, hemorrhagic strokes, nonadjudicated strokes, and prevalent coronary heart disease.