Table 5.
HRs (95% CIs) of Incident Ischemic Stroke, CHD, and the Composite Outcome Comparing 2 vs 0 or 1 APOL1 Risk Variants (Recessive Model), Stratified by CKD Status
| Events/Total N (%) | Crude, HR (95% CI) | Model 1, HR(95% CI) | Model 2, HR (95% CI) | |
|---|---|---|---|---|
| No CKD | ||||
| Ischemic stroke* | 211/7098 (3%) | 1.26 (0.86–1.84) | 1.35 (0.92–1.98) | 1.79 (1.04–3.07) |
| CHD† | 186/6557 (3%) | 1.17 (0.77–1.77) | 1.19 (0.78–1.80) | 0.97 (0.56–1.70) |
| Composite events‡ | 300/6125 (5%) | 1.17 (0.85–1.62) | 1.22 (0.88–1.70) | 1.20 (0.77–1.87) |
| CKD | ||||
| Ischemic stroke* | 158/2315 (7%) | 0.79 (0.49–1.26) | 0.83 (0.51–1.35) | 0.77 (0.36–1.61) |
| CHD† | 137/2033 (7%) | 0.95 (0.59–1.53) | 0.99 (0.60–1.62) | 0.99 (0.55–1.79) |
| Composite events‡ | 200/1783 (11 %) | 0.97 (0.6–1.43) | 1.04 (0.70–1.56) | 1.10 (0.65–1.85) |
Model 1 adjusted for age, sex, smoking, hypertension, lipid-lowering medications, and diabetes mellitus (CKD, events/N: stroke=152/2228; CHD=133/1953; composite=194/1712; no CKD, events/N: stroke=205/6947; CHD=184/6428; composite=296/6007). Model 2 adjusted for variables in model 1 plus ancestry principal components (CKD, events/N: stroke=66/1561; CHD=98/1405; composite=112/1230; no CKD, events/N: stroke=86/4788; CHD=123/4489; composite=161/4205). Pinteraction for CKD on the association of APOL1 high-risk status with incident stroke, CHD, and the composite outcome in the fully adjusted model (model 2) were 0.04, 0.90, and 0.69, respectively. CKD (defined as an estimated glomerular filtration rate <60 mL/min per 1.73 m2 or a spot urine albumin-to-creatinine ratio ≥30 mg/g). CHD indicates coronary heart disease; CI, confidence interval; CKD, chronic kidney disease; and HR, hazard ratio.
Excludes prevalent stroke, hemorrhagic, and nonadjudicated strokes.
Excludes prevalent coronary heart disease.
Excludes prevalent stroke, hemorrhagic strokes, nonadjudicated strokes, and prevalent coronary heart disease.