Table 5 |.
Understudied kinases that are frequently altered in breast cancer
| Gene name | Protein name | TDL | SUM 159 averagea | Alteration frequencyb (%) | Kinase family |
|---|---|---|---|---|---|
| TRIB1 | Tribbles homologue 1 | Tbio | 342 | 24 | CAMK |
| RPS6KC1 | Ribosomal protein S6 kinase δ1 | Tdark | 463 | 23 | Other |
| UHMK1 | Serine/threonine-protein kinase Kist | Tbio | 1,308 | 23 | Other |
| NRBP2 | Nuclear receptor-binding protein 2 | Tdark | 350 | 21 | Other |
| PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type1-α | Tbio | 2,246 | 19 | Metabolic |
| CDK12 | Cyclin-dependent kinase 12 | Tbio | 3,148 | 14 | CMGC |
| MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | Tbio | 455 | 11 | STE |
| STRADA | STE20-related kinase adapter protein-α | Tbio | 464 | 9 | STE |
| BCKDK | (3-methyl-2-oxobutanoate dehydrogenase(lipoamide)) kinase, mitochondrial | Tbio | 1,087 | 6 | Atypical |
| EEF2K | Eukaryotic elongation factor 2 kinase | Tbio | 1,176 | 6 | Atypical |
a
Expression levels in SUM159PT claudin-low triple-negative breast cancer (TNBC) cells.
b
Alteration frequency in breast cancer from The Cancer Genome Atlas (TCGA). TDL, target development level.