Table 1.
Controls | Sporadic bvFTD/MND | C9orf72-bvFTD/MND | |
---|---|---|---|
N | 10 | 17 | 10 |
Clinical diagnoses | N/A | 3 ALS, 1 MND, 2 bvFTD-ALS, 5 bvFTD-MND, 6 bvFTD | 2 ALS, 5 bvFTD-MND, 3 bvFTD |
Neuropathological diagnoses | N/A | 4 ALS-TDP; 2 FTLD-TDP-B, ALS; 8 FTLD-TDP-B, MND; 3 FTLD-TDP-B | 1 ALS-TDP; 5 FTLD-TDP-B, MND; 3 FTLD-TDP-U, MND; 1 FTLD-TDP-U |
Gender (M:F) | 6:4 | 10:7 | 8:2 |
Age at death (years) | 63.6 (9.8) | 61.8 (7.4) | 59.8 (3.4) |
Symptom duration (years) | N/A | 5.2 (2.8) | 7.1 (6.9) |
PMI (hours) | 43.1 (38.2) | 13.0 (10.2) | 13.3 (6.3) |
Broe stage; median (range) | N/A | 1 (0-2) | 1 (0-2) |
Brain weight (g) | 1244 (151) | 1284 (138) | 1257 (172) |
CDR total | N/A | 1.8 (1.1) | 1.3 (0.9) |
CDR Sum of boxes | N/A | 8.9 (5.2) | 7.5 (5.0) |
Worst NPI, sum of apathy, disinhibition, motor, eating | N/A | 41.9 (25.1) | 44.3 (27.5) |
IRI, empathic concern subscale | N/A | 20.0 (8.0) | 17.6 (7.3) |
Unless otherwise noted, numbers in parentheses are SD of preceding mean.