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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Mol Neurobiol. 2018 Jul 19;56(4):2314–2327. doi: 10.1007/s12035-018-1234-2

Figure 6. Potential signaling pathways in the FGF21-FGFR1 protection against T2D-associated BBB permeability involving Keap1-Nrf2.

Figure 6.

Under diabetic conditions, Nrf2 is negatively regulated by Keap1 binding, which leads to ubiquitination and degradation of Nrf2 by the proteasomes. Upon rFGF21 administration, FGFR1 binds to Keap1, which causes Nrf2 dissociation from Keap1 and increased translocation of Nrf2 into the nucleus, eventually leading to activation of cytoprotective genes.