Table 1.

Overview of Studies

Overview				Therapy					Demographics
Study	Pathology	Comparator	SAEs	Kit	Activation	Leukocyes per ul	Platelets per ul	Volume (ml)	Country	Mean Age	Male	Female
Pandey et al. 88, 2016	RC	Repair w/o tx	None Reported	None	CaCl2	4	474,000	8	India	54	74	28
Zou et al.55, 2016	AT	Repair w/o tx	0	WEGO Platelet-Rich Plasma Preparation Kits (WEGO Ltd., Shandong, China)	None	Not reported	Not reported	3–4	China	29	35	1
Seijas et al. 64, 2016	ACL	Repair w/o tx	None Reported	None	CaCl2	Not reported	Not reported	4	Spain	Not reported	37	6
Zumstein et al.89, 2016	RC	Repair w/o tx	0	PRF Process (Nice, France)	None	Not reported	Not reported	Not reported	France	66	18	17
Carr et al.9, 2015	RC	Repair w/o tx	None Reported	Magellan Autologous Platelet Separator System (Arteriocyte)	Thrombin	Not reported	Not reported	<5	Britain	54	27	33
Lebiedziński et al.42, 2015	LE	Betamethasone and lignocaine	None Reported	Arthrex Autologous Conditioned Plasma (ACP) system (Naples, FL, USA)	None	Not reported	Not reported	Not reported	Poland	50	40	59
Jo et al.32, 2015	RC	Repair w/o tx	None Reported	COBE Spectra LRS Turbo; Caridian BCT	Calcium gluconate	40	1,000,000	9*	South Korea	61	27	57
Wang et al. 78, 2015	RC	Repair w/o tx	0	Arthrex Autologous Conditioned Plasma (ACP) system (Naples, FL, USA)	CaCl2	Not reported	470,000	2–4^	Australia	59	28	32
Davenport et al.14, 2015	HT	Whole blood	0	SmartPReP; Harvest Technologies	None	Not reported	Not reported	3	USA	46	3	14
Montalvan et al.48, 2015	LE	Saline	None Reported	Arthrex Autologous Conditioned Plasma (ACP) system (Naples, FL, USA)	None	Not reported	Not reported	2^	France	47	34	16
Tetschke et al. 73, 2015	LE	Laser	0	Arthrex Autologous Conditioned Plasma (ACP) system (Naples, FL, USA)	None	Not reported	Not reported	3–5^	Germany	52	21	31
Behera et al. 6, 2015	LE	Bupivacaine	0	None	CaCl2	600–800	600,000–800,000	3	India	38	7	17
Gautam et al25., 2015	LE	Corticosteroid	None Reported	None	None	Not reported	Not reported	2	India	Not reported	N/A	NA
Malavolta et al.44, 2014	RC	Repair w/o tx	0	MCS+ 9000 blood cell separator and 994-CFE apheresis set	Thrombin	Not reported	Not reported	20	Brazil	55	17	37
Dragoo et al. 23, 2014	PT	Dry needling	0	GPS III Platelet Separation System (Biomet Biologics, Warsaw, Indiana)	None	Not reported	Not reported	6	USA	33	20	1
Raeissadat et al.57, 2014	LE	Autologous whole blood	0	Rooyagen kit (Arya Mabna Tashkhis Corporation, RN: 312569)	None	6740	1,227,000	2	Iran	44	14	47
Raeissadat et al.58, 2014	LE	Autologous whole blood	0	Rooyagen kit (Arya Mabna Tashkhis Corporation, RN: 312569)	None	Not reported	990,000	2	Iran	46	8	32
Kesikburun et al.34, 2013	RC	Saline	0	GPS III Platelet Separation System (Biomet Biologics, Warsaw, Indiana)	None	Not reported	1,014,900	5	Turkey	53	13	27
Krogh et al.38, 2013	LE	Saline or glucocorticoid	0	Recover GPS II system (Biomet Biologics Inc, Warsaw, Indiana)	None	Not reported	Not reported	3–3.5	Denmark	45	31	29
Weber et al.80, 2013	RC	Repair w/o tx	None Reported	Cascade system (Musculoskeletal Transplant Foundation, Edison, New Jersey)	Calcium	Not reported	Not reported	Not reported	USA	62	36	24
Rha et al.60, 2013	RC	Dry needling	0	Prosys PRP Platelet Concentration System	None	Not reported	Not reported	3	South Korea	53	17	22
Jo et al.31, 2013	RC	Repair w/o tx	None Reported	COBE Spectra LRS Turbo; Caridian BCT	Calcium gluconate	40	1,000,000	9*	South Korea	63	24	24
Vetrano et al.76, 2013	PT	Extracorporeal shock wave therapy	0	MyCells Autologous Platelet Preparation System (Kaylight Ltd, RamatHasharon, Israel)	None	Not reported	0.89–1.1 × 10^12	4~	Italy	27	37	9
Ruiz-Moneo et al.61, 2013	RC	Repair w/o tx	0	PRGF System1, B.T.I. Biotechnology Institute, Vitoria-Gasteiz, Spain	CaCl2	0	600,000	Not reported	Spain	56	30	39
de Almeida et al.15, 2012	ACL	Repair w/o tx	0	Haemonetics MCS1 9000 cell separato + specific kit for platelet apheresis 995-E (Haemonetics Corp, Braintree, Massachusetts)	CaCl2	0.91	1,185,166	20–40*	Brazil	24	24	3
Gumina et al., 2012	RC	Repair w/o tx	None Reported	RegenKit; Regen Lab, Le MontSur-Lausanne, Switzerland)	None	7000	400,000	0.4–0.5*	Italy	61	41	35
Cervellin et al., 2012	ACL	Repair w/o tx	0	GPS II - Plasmax - Platelet Concentration System (Biomet Biologics, Warsaw, IN, USA)	CaCl2 and Thrombin	Not reported	Not reported	Not reported	Italy	23	40	0
Creaney et al.13, 2011	LE	Whole blood	None Reported	None	None	Not reported	652,000	2	United Kingdom	51	74	56
Peerbooms et al.56, 2010 // Gosens et al.27, 2011	LE	Corticosteroid	0	Recover™ Platelet Separation Kit (Biomet Biologics, Warsaw, Indiana)	None	Not reported	Not reported	3	Netherlands	47	48	52
de Jonge et al.16, 2011 // de Vos et al.17, 2011 // de Vos et al.18, 2010	AT	Saline	0	GPS III Platelet Separation System (Biomet Biologics, Warsaw, Indiana)	Soluble type I collagen	Not reported	Not reported	4	Netherlands	50	26	28
Randelli et al.59, 2011	RC	Repair w/o tx	0	GPS II - Plasmax - Platelet Concentration System (Biomet Biologics, Warsaw, IN, USA)	CaCl2 and Thrombin	Not reported	Not reported	6	Italy	61	21	42
Castricini et al., 2011	RC	Repair w/o tx	0	None	CaCl2	Not reported	Not reported	Not specified	Italy	55	40	48
Thanasas et al.10, 2011	LE	Whole blood	0	GPS III Platelet Separation System (Biomet Biologics, Warsaw, Indiana)	None	11,644	1,292,500	3	Greece	36	8	21
Nin et al.51, 2009	ACL	Repair w/o tx	None Reported	None	CaCl2	Not reported	837,000	4*	Spain	26	78	22

^~multiple treatments

^*PRP gel

^{^}ACP