Table 2.

Risk factors for complications that contraindicate ambulatory management

Organ or system	Risk factor
Vascular	Syncope, systolic blood pressure < 90 mmHg, hypertensive crisis, arrhythmias, heart failure, clinically relevant bleeding, angina pectoris
Hematological	Other clinically relevant cytopenias (platelets < 50,000/μL, Hb < 8 g/dL), thromboembolic disease
Gastrointestinal	Oral intolerance, vomiting, diarrhea, pain abdominal, jaundice, alteration of liver function tests
Infectious	Sepsis or severe focus (pneumonia, extensive cellulitis, bacteremia, catheter, pyelonephritis, meningitis, cholecystitis, and other surgical infections), allergy to antibiotics, recent use of antibiotics
Neurological	Presence of focal neurological symptoms, suspicion of meningitis, acute confusional syndrome
Pulmonary	Abscesses, pneumothorax, pleural effusion, acute respiratory failure, pulmonary infiltrates, or cavitary nodules
Others	Acute kidney failure, dehydration, electrolyte alterations, other alterations of vital signs, other complications considered severe, pregnancy, fractures