Level of agreement |
I |
Accepted completely |
II |
Accepted with some reservation |
III |
Accepted with major reservation |
IV |
Rejected with reservation |
V |
Rejected completely |
Level of evidence |
I |
Evidence obtained from at least one randomized controlled trial |
II-1 |
Evidence obtained from well-designed controlled trials without randomization |
II-2 |
Evidence obtained from well-designed cohort or case-controlled study |
II-3 |
Evidence obtained from the comparison between time and places with or without intervention |
III |
The opinion of respected authorities, based on experience or expert committees |
Recommendation (based on the quality of evidence) |
A |
There is good evidence to support the statement |
B |
There is fair evidence to support the statement |
C |
There is poor evidence to support the statement but recommendation made on other grounds |
D |
There is fair evidence to refute the statement |
E |
There is good evidence to refute the statement |