Table 1.

Antibacterial activity of the most potent three UppS inhibitors against wild-type and efflux pump-deficient E. coli BW25113 strains with (+PMB) or without (−PMB) polymyxin B-formed permeable membrane.

	MIC (μg/mL)
	BW25113		BW25113 ΔacrA		BW25113 ΔacrB		BW25113 ΔtolC
	−PMB	+PMB	−PMB	+PMB	−PMB	+PMB	−PMB	+PMB
1	>32	>32	>32	2	>32	2	>32	>32
2	>32	>32	>32	>32	>32	>32	0.5	0.5
3	>32	>32	>32	2	>32	2	>32	>32