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. 2019 Jan 14;5:364. doi: 10.3389/fmed.2018.00364

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Copyright © 2019 Robert and Miossec.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interleukin (IL)-17 and Receptor family involved in rheumatoid arthritis. IL-17A and IL-17F homodimers and the IL-17A/IL-17F heterodimer bind the same receptor composed of IL-17RA and IL-17RC subunits. IL-17RA is also involved in IL-17E (also known as IL-25) receptor with IL-17RB. IL-17A/F and IL-17E have distinct biological effects, the first triggers inflammation and granulopoiesis; the latter promotes T-helper (Th) 2 responses in host defense against parasites and allergy. IL-17E also regulates Th17 inflammatory response.