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. 2019 Jan 14;5:364. doi: 10.3389/fmed.2018.00364

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Copyright © 2019 Robert and Miossec.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of Interleukin (IL)-17 function. Various mediators regulate IL-17A function. Some have additive or synergistic effects with IL-17A as tumor necrosis factor-α (TNFα), IL-1, granulocyte-macrophage colony stimulating factor (GM-CSF) and interferon (IFN) γ. Conversely, IL-25 (also known as IL-17E), anti-IL-17 autoantibodies and soluble IL-17 receptor (sIL-17R) inhibit IL-17 function.