Table 1.

Comparison of iVikodak with other function inference tools.

Features	iVikodak	Burrito	Vikodak	PICRUSt	Tax4Fun
Multivariate inputs	✓	✓	✓	✓	✓
Default RDP compatibility	✓	×	✓	×	✓
Default Greengenes compatibility	✓	✓	×	✓	×
Default SILVA compatibility	✓	×	✓	×	✓
KEGG, Pfam, COG, TIGRfam inference	✓	✓	×	✓	×
In-depth analysis of pathway of interest	✓	×	✓	×	×
Co-inhabitance based algorithms	✓	×	✓	×	×
Gene Quorum Assumption	✓	×	✓	×	×
Metadata acceptance	✓	✓	✓	×	×
Multiple Categories of Metadata acceptance	✓	×	✓	×	×
Tools for Statistical Comparisons	✓	✓	×	×	×
Graphical Visualizations	✓	✓	×	×	×
- Ordination (PCoA)	✓	×	×	×	×
- Core Functions (Heatmaps)	✓	×	×	×	×
- Top Functions (Grouped Box plots)	✓	×	×	×	×
- Top Functions (Grouped Bar plots)	×	✓	×	×	×
- Differentiating functions (Heatmaps)	✓	×	×	×	×
- Differentiating functions (Cladograms)	✓	×	×	×	×
- Taxa – Function Contribution tree	✓	✓	×	×	×
- Function-driven Networks	✓	×	×	×	×
- Enzyme Abundance Profiles (Heatmaps)	✓	×	×	×	×
3D and Colored KEGG Pathway Maps	✓	×	×	×	×
Task Management (multi-jobs, JOB IDs etc.)	✓	×	×	×	×
Personalized and Portable Dashboards	✓	×	×	×	×