Table 1.
Degree of coverage of RA elements with pathways vulnerable to AFlut for different substrates and antiarrhythmic drugs amiodarone (amio) and dronedarone (drone).
Degree of coverage | ||||||
---|---|---|---|---|---|---|
Original CV | Total activation time matched | |||||
no drug | amio | drone | no drug | amio | drone | |
Control | 18.1% | 70.5% | 0.0% | 18.1% | 0.0% | 0.0% |
cAF | 96.0% | 96.3% | 95.6% | 96.2% | 96.1% | 94.9% |
N588K | 93.2% | 94.1% | 0.0% | 93.0% | 77.8% | 0.0% |
L532P | 96.2% | 96.5% | 34.5% | 96.3% | 96.0% | 11.1% |
In the right three columns, the A and B values determining the CV according to Equation (3) were scaled to match the activation time of the last element during sinus rhythm in the control substrate with no drug applied.