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. 2019 Jan 14;9:1910. doi: 10.3389/fphys.2018.01910

Table 1.

Degree of coverage of RA elements with pathways vulnerable to AFlut for different substrates and antiarrhythmic drugs amiodarone (amio) and dronedarone (drone).

Degree of coverage
Original CV Total activation time matched
no drug amio drone no drug amio drone
Control 18.1% 70.5% 0.0% 18.1% 0.0% 0.0%
cAF 96.0% 96.3% 95.6% 96.2% 96.1% 94.9%
N588K 93.2% 94.1% 0.0% 93.0% 77.8% 0.0%
L532P 96.2% 96.5% 34.5% 96.3% 96.0% 11.1%

In the right three columns, the A and B values determining the CV according to Equation (3) were scaled to match the activation time of the last element during sinus rhythm in the control substrate with no drug applied.