Table 3.
Inhibitory concentration 50 (IC50) of frog skin-derived antimicrobial peptides against amphibian viral pathogens.
| Virus | Species | AMP | Sequence | IC50(μM) | References |
|---|---|---|---|---|---|
| Frog virus 3 | Phyllomedusa sauvagii | Dermaseptin-S1 | ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ | 12 | (10) |
| Rana catesbeiana | Skin peptide mixture | ND | (10) | ||
| Rana pipiens | Skin peptide mixture | ND | (10) | ||
| Rana temporaria | Temporin A | FLPLIGRVLSGIL.NH2 | 58 | (10) | |
| Xenopus laevis | Magainin II | GIGKFLHSAKKFGKAFVGEIMNS | ND | (10) | |
| PGLa | GMASKAGAIAGKIAKVALKAL.NH2 | ND | (10) |
ND indicates not determined (i.e., at the level tested, the AMP or skin peptide mixture was found to have no effect on the pathogen). Values are reported in μM where available.