| Study characteristic | First author/publication year | ||
|---|---|---|---|
| Bing 1981 | Zacharias 1981 | Milia 2006 | |
| 16‐week follow‐up | 12‐week follow‐up | ||
| Group size (per protocol) | |||
| Indapamide | 8 | Assumed 8 | 13 |
| Bendroflumethiazide | 7 | Assumed 8 | 12 |
| Withdrawals for medical reasons | |||
| Indapamide | 1 (dizziness) | 1 (at 20 weeks due to depression) | 0 |
| Bendroflumethiazide | 3 (1 dizziness; 2 uncontrolled hypertension) | 0 | 1 (viral illness) |
| Withdrawals for nonmedical reasons | |||
| Indapamide | 1 (failed to complete the study) | 0 | 0 |
| Bendroflumethiazide | 0 | 0 | 0 |
| Systolic blood pressure, supine (mmHg) | |||
| Indapamide | |||
| Baseline mean (SD) | No information | 172 | 145 (15.5) |
| Mean change from baseline (SD) | −20.2 (19.9) | −15a | −14.7 (12.5) |
| Bendroflumethiazide | |||
| Baseline mean (SD) | No information | 181 | 134.8 (19.3) |
| Mean change from baseline (SD) | −14.1 (19.9) | −22a | −7.7 (9.16) |
| Diastolic blood pressure, supine (mmHg) | |||
| Indapamide | |||
| Baseline mean (SD) | No information | 101 | 78.3 (7.4) |
| Mean change from baseline (SD) | −6.4 (6.9)a | −10 | −7.8 (5.7)a |
| Bendroflumethiazide | |||
| Baseline mean (SD) | No information | 104 | 73.4 (10.4) |
| Mean change from baseline (SD) | −3.7 (6.9)a | −11 | −3.67 (4.9)a |
| Authors’ conclusion | Indapamide produced a significant but equivalent fall in blood pressure to that observed with bendroflumethiazide | Both drugs produced a similar, modest improvement in blood pressure | Both diuretics reduced blood pressure to a similar and significant degree |
SD, standard deviation
a
Estimated from information in the paper