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. 2019 Jan 9;9(1):e025464. doi: 10.1136/bmjopen-2018-025464

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Overview of the study design. Blood samples are taken during a regular blood withdrawal at six time points (4–8 weeks before BS, BS, 6 months after BS, 24 months after BS, and 5 and 10 years after BS). Microbiota analyses will be performed at set time points on the faeces (collected at home by the patients) (4–8 weeks before BS, 1 week before BS, 6 months after BS, 24 months after BS) and mucosal swabs (collected during surgery). Furthermore, biopsies of liver, jejunum and adipose tissue depots (subcutaneous, mesenteric and omental) will be collected during surgery. Before surgery (4–8 weeks before BS) and at several time points after (6 months after BS, 24 months after BS, and 5 and 10 years after BS), a medical evaluation will take place and all patients will complete questionnaires and neuropsychological measurements to test cognitive function. A subgroup of patients (n=75) will be examined with MRI (4–8 weeks before BS and 24 months after BS). BS, bariatric surgery.