FIG 4.

Presence of viral VP1 protein in various organs in humanized mice after EV-A71 infection. Four-week-old humanized mice were inoculated i.p. with or without EV-A71 (10⁸ PFU/mouse). Representative photomicrographs of immunohistochemistry for different organs among mock-infected mice (n = 5), EV-A71-infected surviving mice (n = 6), and moribund mice (n = 4) are shown. VP1-positive signals were detected in different organs in the EV-A71-infected surviving mice and moribund mice. The boxes depict magnified areas. Bars, 100 μm.