FIG 8.
EV-A71 infection stimulates the secretion of proinflammatory cytokines in humanized mice. Four-week-old humanized mice were inoculated i.p. with or without EV-A71 (108 PFU/mouse). Serum samples were collected at the indicated weeks postinfection. Serum level of human IFN-γ (A), IL-8 (B), and IL-17A (C) was determined by a LEGENDplex human inflammation panel (n = 4 for mock-infected group; n = 8 for EV-A71-infected group). The dotted line in each graph represents the minimum detectable concentration of each cytokine. Data are expressed as means ± SEM. *, P < 0.05; **, P < 0.01.