FIG 1.

Heat map of hierarchical clustering analysis of the HHV-6B transcriptome from whole blood, DLBCL tumor tissue, and SupT1 CD4⁺ T cells with lytic HHV-6B Z29 infection. We performed hierarchical clustering analysis to compare the normalized read numbers mapped to each HHV-6B gene in whole blood, DLBCL tumor tissue, and SupT1 CD4⁺ T cells with lytic HHV-6B Z29 infection (48 h postinfection). Hierarchically clustered viral genes (rows) from each sample type (columns) are shown in dendrograms and demonstrate differential clustering. Cases 1, 2, 3, and 7 are from whole-blood samples in subjects with HHV-6B DNA detection in plasma after allogeneic HCT. DLBCLs I and II are tumor tissue samples from two individuals with DLBCL. DLBCL I was coinfected with Epstein-Barr virus.