Figure 6.

Depletion of Cblb^−/−Apoe^−/− CD8⁺ T cells reduces inflammation in initial atherosclerotic plaques. (A) Apoe^−/− mice were lethally irradiated and reconstituted with Apoe^−/− or Cblb^−/−Apoe^−/− bone marrow and either treated with a CD8⁺ T cell depleting antibody or isotype control for 6 weeks. (B) CD8⁺ T cell numbers in the blood of isotype and anti-CD8-treated mice. (C, D) Immunohistochemical quantification of the relative number of CD45⁺ cells. And representative pictures of CD45-stained aortic arch sections containing initial atherosclerotic plaques. Scale bar: 100 μm. (E) Quantification of plaque macrophage content. Data are presented as mean ± standard deviation (n = 11–14).