Table 2.
Gene Ontology (GO) analysis for miR-146a-5p, miR-149-5p, miR-509-3p and miR-182-5p.
| miR-146a-5p (up in MGCs) | GO Term | # genes | FDR |
|---|---|---|---|
| Pathways in cancer | 15 | 3.77E-07 | |
| Mutagenesis site | 20 | 8.54E-07 | |
| Cellular response to mechanical stimulus | 7 | 1.04E-05 | |
| Toll-like receptor signalling pathway | 9 | 1.62E-05 | |
| Inflammatory response | 10 | 8.93E-05 | |
| Positive regulation of smooth muscle cell proliferation | 6 | 2.26E-04 | |
| Chagas disease (American trypanosomiasis) | 8 | 3.27E-04 | |
| Ubl conjugation | 15 | 5.26E-04 | |
| Lipopolysaccharide-mediated signaling pathway | 5 | 8.39E-04 | |
| Leishmaniasis | 7 | 6.68E-04 | |
| Protein binding | 33 | 7.99E-04 | |
| Toxoplasmosis | 8 | 7.77E-04 | |
| miR-182-5p (up in CCs) | Tumor suppressor | 9 | 2.20E-06 |
| Ubl conjugation | 18 | 9.56E-06 | |
| Nucleus | 29 | 1.18E-05 | |
| Positive regulation of transcription, DNA-templated | 12 | 4.28E-05 | |
| Sequence-specific DNA binding | 12 | 3.36E-05 | |
| Prostate cancer | 8 | 4.66E-05 | |
| Negative regulation of apoptotic process | 11 | 1.57E-04 | |
| Nucleoplasm | 21 | 5.40E-04 | |
| PI3K-Akt signaling pathway | 11 | 5.67E-04 | |
| Cellular response to DNA damage stimulus | 8 | 9.77E-04 | |
| miR-182-5p, miR-509-3p, miR-149-5p (all up in CCs) | Ubl conjugation | 23 | 3.91E-08 |
| Positive regulation of transcription, DNA-templated | 15 | 5.22E-07 | |
| Sequence-specific DNA binding | 14 | 4.81E-06 | |
| Tumor suppressor | 9 | 1.65E-05 | |
| Prostate cancer | 9 | 1.69E-05 | |
| Nucleus | 33 | 4.97E-05 | |
| Negative regulation of apoptotic process | 12 | 1.79E-04 | |
| PI3K-Akt signaling pathway | 13 | 1.40E-04 | |
| Positive regulation of transcription from RNA polymerase II promoter | 16 | 2.59E-04 | |
| Cellular response to DNA damage stimulus | 9 | 3.59E-04 | |
| Phosphoprotein | 40 | 3.83E-04 | |
| Transcription regulation | 21 | 4.57E-04 | |
| Pathways in cancer | 13 | 5.79E-04 | |
| Transcription | 21 | 7.17E-04 | |
| Activator | 12 | 7.44E-04 |
FDR= false discovery rate