Table 1.
Prevalence of thyroid dysfunction and of positive thyroid antibodies according to the type of dysfunction.
|
Thyroid
Dysfunction |
Prevalence
n (%) |
Men/Women
n / n |
Age
Mean (SD) |
TPOAb +
n (%) |
TgAb +
n (%) |
Any TAb
n (%) |
Both TAb
n (%) |
|---|---|---|---|---|---|---|---|
| Any Hypo | 24 (4.9) a | 6/18 | 59.0 (14.8) | 10 (41.7) | 9 (37.5) | 11 (45.8) | 8 (33.3) |
| PD Hypo | 7 (1.4) | 0/7 | 59.6 (9.2) | 4 (57.1) | 3 (42.9) | 4 (57.1) | 3 (42.9) |
| UD Hypo | 17 (3.5) | 6/11 | 58.8 (16.8) | 6 (35.3) | 6 (35.3) | 7 (41.2) | 5 (29.4) |
| Overt Hypo | 1 (0.2) | 1/0 | 76.0 (-) | 0 | 1 (100.0) | 1 (100.0) | 0 |
| SCH - severe | 3 (0.6) | 0/3 | 52.0 (6.2) | 3 (100.0) | 2 (66.7) | 3 (100.0) | 2 (66.7) |
| SCH - mild | 13 (2.7) | 5/8 | 59.0 (18.2) | 3 (23.1) | 3 (23.1) | 3 (23.1) | 3 (23.1) |
| Euthyroidism | 450 (92.6) | 197/253 | 53.1 (16.2) | 47 (10.4) | 63 (14.0) | 80 (17.8) | 30 (6.7) |
| Any Hyper | 12 (2.5) b | 2/10 | 56.0 (15.8) | 1 (8.3) | 1 (8.3) | 1 (8.3) | 1 (8.3) |
| PD Hyper | 3 (0.6) | 0/3 | 56.7 (26.1) | 0 | 0 | 0 | 0 |
| UD Hyper | 9 (1.9) | 2/7 | 55.8 (13.1) | 1 (11.1) | 1 (11.1) | 1 (11.1) | 1(11.1) |
| Overt Hyper | 2 (0.4) | 1/1 | 55.0 (12.7) | 1 (50.0) | 1 (50.0) | 1 (50.0) | 1 (50.0) |
| SHyper grade 2 | 3 (0.6) | 0/3 | 54.7 (18.8) | 0 | 0 | 0 | 0 |
| SHyper grade 1 | 4 (0.8) | 1/3 | 57.0 (12.9) | 0 | 0 | 0 | 0 |
| Any TD | 36 (7.4) c | 8/28 d | 58.0 (15.0) | 11 (30.6) | 10 (27.8) | 12 (33.3) | 9 (25.0) |
| PD TD | 10 (2.1) | 0/10 | 58.7 (14.5) | 4 (40.0) | 3 (30.0) | 4 (40.0) | 3 (30.0) |
| UD TD | 26 (5.3) | 8/18 | 57.7 (15.4) | 7 (26.9) | 7 (26.9) | 8 (30.8) | 6 (23.1) |
| Overt TD | 3 (0.6) | 2/1 | 62.0 (15.1) | 1 (33.3) | 2 (66.7) | 2 (66.7) | 1 (33.3) |
| Subclinical TD | 23 (4.7) | 6/17 | 57.2 (15.7) | 6 (26.1) | 5 (21.7) | 6 (26.1) | 5 (21.7) |
| Total | 486 (100) | 205/281 | 53.5 (16.2) | 58 (11.9) e | 73 (15.0) f | 92 (18.9) g | 39 (8.0) |
Two of the 486 participants included in the analysis had no TgAb assay (one with a prior diagnosis of hypothyroidism and one with normal thyroid function).
SD: standard deviation; TPOAb: thyroid peroxidase antibodies; TgAb: thyroglobulin antibodies; TAb: thyroid antibodies; Hypo: hypothyroidism; Hyper: hyperthyroidism; SCH: subclinical hypothyroidism; SHyper: subclinical hyperthyroidism; TD: thyroid dysfunction; PD: previously diagnosed; UD: undiagnosed.
a Prevalence of 2.4% and 6.8% (p=0.027) respectively below and above 50 years of age; b prevalence of 2.4% and 2.5% (p=0.948), respectively, below and above 50 years of age; c prevalence of 4.8% and 9.3% (p=0.062), respectively, below and above 50 years of age; d thyroid dysfunction was significantly more frequent in women: p=0.012; e 16.7% in women and 5.4% in men: p˂0.001; f 21.5% in women and 6.8% in men: p˂0.001; g 28.5% in women and 10.2% in men: p˂0.001.