Table 3.
Associations of thyroid antibody positivity with metabolic syndrome, its components and other variables.
| - | TPOAb (+) | TgAb (+) |
|---|---|---|
| Categorical variables | OR (95% CI) | OR (95% CI) |
| Metabolic syndrome | 0.465 (0.236, 0.917)* | 0.841 (0.474, 1.493) |
| WC component | 0.984 (0.528, 1.836) | 0.893 (0.513, 1.552) |
| BP component | 0.788 (0.394, 1.575) | 1.019 (0.546, 1.904) |
| TG component | 0.321 (0.124, 0.836)* | 0.710 (0.361, 1.394) |
| HDL-C component | 0.792 (0.440, 1.425) | 1.309 (0.764, 2.243) |
| Glucose component | 0.637 (0.288, 1.410) | 0.764 (0.377, 1.547) |
| Gender (men) | 0.294 (0.147, 0.558)* | 0.282 (0.152, 0.524)* |
| Weight status Pre-obese | 0.900 (0.442, 1.822) | 0.969 (0.516, 1.823) |
| Obese | 1.400 (0.667, 2.936) | 1.370 (0.698, 2.687) |
| TPOAb positivity | - | 22.128 (11.042, 44.343)* |
| TgAb positivity | 21.933 (10.968, 43.863)* | - |
| Continuous variables | β (95% CI) | β (95% CI) |
| Age (years) | 3.202 (-1.458, 7.862) | 0.876 (-3.324, 5.076) |
| WC (cm) | 0.546 (-2.682, 3.773) | 0.554 (-2.345, 3.452) |
| BMI (kg/m2) | 0.190 (-0.433, 2.176) | 0.170 (-0.352, 1.994) |
| Systolic BP (mmHg) | -3.113 (-8.471, 2.245) | 0.227 (-4.623, 5.076) |
| Diastolic BP (mmHg) | -1.459 (-4.707, 1.708) | 0.195 (-2.742, 3.132) |
| TG (mg/dL) | -0.055 (-0.231, 0.120) | -0.039 (-0.197, 0.119) |
| LDL-C (mg/dL) | 0.969 (-9.653, 11.590) | -4.384 (-13.925, 5.158) |
| HDL-C (mg/dL) | 0.009 (-0.025, 0.043) | -0.007 (-0.037, 0.024) |
| Glucose (mg/dL) | 0.003 (-0.077, 0.084) | 0.015 (-0.058, 0.088) |
| HOMA | -0.036 (-0.686, 0.615) | 0.267 (-0.321, 0.855) |
| Insulin (µlU/mL) | 0.369 (-1.547, 2.285) | 0.751 (-0.971, 2.473) |
| hs-CRP (mg/L) | -0.047 (-0.199, 0.105) | 0.037 (-0.099, 0.174) |
Logistic and linear regression models adjusted for age and sex. This analysis included 479 subjects. Participants with previously diagnosed hypothyroidism and under treatment with L-thyroxine were excluded (n=7). The reference class for weight status was “normal range”.
BMI: body mass index; WC: waist circumference; BP: blood pressure; TG: triglycerides; HDL-C: HDL cholesterol; LDL cholesterol; HOMA-IR: homeostatic model assessment-insulin resistance; hs-CRP: high-sensitivity C-reactive protein; TPOAb: thyroid peroxidase antibodies; TgAb: thyroglobulin antibodies.
* p˂0.05.