Table 2.
Concentrations of fecal inflammation markers and fecal bacterial strains (mean + SD, range in brackets) in patients with Alzheimer’s dementia (n = 18) before and after 28 days of a multi-specific probiotic supplementation.
Before | After | |
---|---|---|
Mean + SD (Range) | Mean + SD (Range) | |
α1-Antitrypsin [mg/g] | 37.9 ± 23.7 (9.6 - 282) | 44.7 ± 35.8 (6.2 - 520) |
Calprotectin [mg/L] | 84.7 ± 71 (2.8 - 112) | 119 ± 131 (3.8 - 123) |
Zonulin [µg/L] | 93.1 ± 56.3 (16 - 220) | 66.6 ± 54.2 (19 - 213)** |
S100A12 [µg/L] | 3.5 + 6.0 (0 - 23) | not available |
Clostridium cluster I* | 7.76 ± 1.10 (5.46 - 9.26) | 7.92 ± 1.28 (5.34 - 10.2) |
Faecalibacterium prausnitzii* | 8.25 ± 1.47 (5.15 – 10.1) | 9.04 ± 1.43 (5.83 - 10.9) *** |
Akkermansia muciniphila* | 8.61 ± 1.67 (6.00 – 10.9) | 8.47 ± 1.85 (6.00 - 10.8) |
(*RNA copy/g feces, log10; **U = 2.461, p = 0.01; ***U = 3.375, p <0.001).