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. 2019 Jan;60(1):265–273. doi: 10.1167/iovs.18-25477

Figure 7.

Figure 7

Increased mRNA expression of ER stress markers started from 6 hours after TUN treatment. TMSCs and TM cells (TM) were incubated with 5 μg/mL TUN for different time points. mRNA levels were shown relative to DMSO controls at each time point. For DMSO controls, fold change was calculated based on the DMSO controls at 1 hour. Increase of GRP78 expression started at 6 hours and peaked at 12 hours in TMSCs and at 24 hours in TM cells. Increase of CHOP and sXBP1 expression peaked at 12 hours in TMSCs and TM cells, whereas the increase lasted longer in TM cells. Results are shown as mean ± SEM (n = 3). *TUN treatment groups versus DMSO controls; #TMSCs and TM cells with TUN treatment. */#P < 0.05, **/##P < 0.01, ***/###P < 0.001. Two-way ANOVA followed by Dunnett's multiple comparison test.