Table 4.
Subgroup analysis of the GSTP1 rs1695 A/G polymorphism by SCC type
| Subgroup | Index | Allele | Carrier | Homozygote | Heterozygote | Dominant | Recessive |
|---|---|---|---|---|---|---|---|
| ESCC | OR (95% CIs) | 1.05 (0.96~1.15) | 1.03 (0.93~1.14) | 1.15 (0.95~1.39) | 1.00 (0.88~1.14) | 1.03 (0.92~1.17) | 1.13 (0.95~1.34) |
| P a | 0.263 | 0.568 | 0.155 | 0.970 | 0.575 | 0.160 | |
| Case/control | 1934/3951 | 1934/3951 | 1934/3951 | 1934/3951 | 1934/3951 | 1934/3951 | |
| Study number | 15 | 15 | 15 | 15 | 15 | 15 | |
| HNSCC | OR (95% CIs) | 0.95 (0.89~1.01) | 0.96 (0.89~1.03) | 0.94 (0.82~1.09) | 0.94 (0.87~1.02) | 0.93 (0.86~1.01) | 0.95 (0.83~1.09) |
| P a | 0.112 | 0.247 | 0.408 | 0.131 | 0.102 | 0.459 | |
| Case/control | 4671/4961 | 4671/4961 | 4671/4961 | 4671/4961 | 4671/4961 | 4671/4961 | |
| Study number | 18 | 18 | 18 | 18 | 18 | 18 | |
| LSCC | OR (95% CIs) | 1.00 (0.93~1.08) | 1.00 (0.92~1.09) | 1.04 (0.88~1.24) | 0.97 (0.87~1.07) | 0.98 (0.89~1.09) | 1.06 (0.90~1.25) |
| P a | 0.940 | 0.973 | 0.616 | 0.526 | 0.741 | 0.485 | |
| Case/control | 2574/5421 | 2574/5421 | 2574/5421 | 2574/5421 | 2574/5421 | 2574/5421 | |
| Study number | 15 | 15 | 15 | 15 | 15 | 15 | |
| SSCC | OR (95% CIs) | 0.91 (0.70~1.19) | 0.94 (0.69~1.28) | 0.83 (0.46~1.49) | 0.94 (0.64~1.36) | 0.91 (0.64~1.30) | 0.86 (0.49~1.51) |
| P a | 0.493 | 0.688 | 0.532 | 0.728 | 0.605 | 0.597 | |
| Case/control | 177/475 | 177/475 | 177/475 | 177/475 | 177/475 | 177/475 | |
| Study number | 3 | 3 | 3 | 3 | 3 | 3 |
ESCC oesophageal squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma, LSCC lung squamous cell carcinoma, SSCC skin squamous cell carcinoma, OR odds ratio, CIs confidence intervals, Pa, P value of association test