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. 2019 Jan 14;9:741. doi: 10.3389/fpsyt.2018.00741

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Copyright © 2019 Yin, Zhou, Yan and Lou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart demonstrating our imaging process for each subject. The 3DT1 image (A) was segmented to white mater mapping (B) automatically on Statistical Parametric Mapping (SPM). Then the T2-FLAIR image (C) was co-registered to 3DT1 image. White matter hyperintensity (WMH) lesion segmentation was based on co-registered T2FLAIR image (C) on Lesion Segmentation Tool in SPM. Normal-appearing white mater mapping (D) was obtained by image subtraction of white mater mapping and WMH lesion.