Table 1.
Main characteristics of CADASIL patients.
| Variable | N = 29 (mean ± SD) or n (%) |
|---|---|
| Age at disease onset (year) | 42.0 ± 9.4 |
| Age at first neurological examination (year) | 48.4 ± 7.9 |
| Female | 17 (58.6%) |
| Clinical features | |
| Ischemic TIA/stroke | 17 (58.6%) |
| MMSE score | 23.8 ± 6.9 |
| Migraine with aura | 10 (34.5%) |
| Family history | 25 (86.2%) |
| Vascular risk factors | |
| Hypertension | 4 (13.8%) |
| Diabetes | 1 (3.4%) |
| Hyperlipidemia | 6 (20.7%) |
| Smoking | 6 (20.7%) |
| Neuroimaging findings | |
| Lesion load of WMH (ml) | 64.1 ± 31.7 |
| Temporal poles hyperintensity | 18 (62.1%) |
| External capsule involvement | 21 (72.4%) |
| Subcortical infarcts | 20 (69.0%) |
| Single | 3 (15.0%) |
| Multiple | 17 (85.0%) |
CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; SD, standard deviation; TIA, transient ischemic attack; MMSE, Mini-mental state examination; WMH, white matter hyperintensity.