Table 3.
Univariate and multivariate linear regression analyses of imaging variables with MMSE score.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Standardized β | P value | Standardized β | P value | |
| FA-WMH | 0.378 | 0.043 | 0.262 | 0.386 |
| FA-NAWM | 0.337 | 0.074 | – | – |
| MD-WMH (10−9 m2/s) | −0.409 | 0.028 | −0.133 | 0.602 |
| MD-NAWM (10−9 m2/s) | −0.285 | 0.134 | – | – |
| CBF-WMH (mL/100g/min) | 0.452 | 0.014 | 0.485 | 0.015 |
| CBF-NAWM (mL/100g/min) | 0.439 | 0.017 | 0.205 | 0.565 |
MMSE, Mini-mental state examination; FA, fractional anisotropy; WMH, white matter hyperintensity; NAWM, normal-appearing white matter; MD, mean diffusivity; CBF, cerebral blood flow. Age, gender, lesion load of WMH, and the presence of subcortical infarcts were adjusted in the multiple linear regression models. Bold indicates p < 0.05.