Figure 1.

Herpes simplex virus type 1 (HSV-1)-infected mice present elevated levels of Arc protein. (A) Cortexes from mock and HSV-1 infected mice (six animals per time and condition) were stained at 15, 60 days post-infection (dpi) post-infection with antibodies to Arc and to ICP8 (three slices per animal). Magnification 100×, scale bar represents 100 nm. (B,C) Graphics show the number of Arc/ICP8 positive cells/mm² (n = 3 sections per times). ****p < 0.0001 and ***p < 0.001 [analyzed by Two-Way analyses of variance (ANOVA)]. Statistical analyses between mock times to Arc and ICP8 were not significant. Also were not significant to ICP8 in infected times at 15 dpi compared to 60 dpi.