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. 2019 Jan 8;12:505. doi: 10.3389/fncel.2018.00505

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Copyright © 2019 Acuña-Hinrichsen, Muñoz, Hott, Martin, Mancilla, Salazar, Leyton, Zambrano, Concha, Burgos and Otth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Viral replication is mandatory to induce an increase in Arc protein levels. (A) Immunoblot analyses showing Arc, ICP8, Actin and GAPDH proteins, in either mock or HSV-1-infected neurons (lanes 1–6) with a MOI of 10 and at 8 hpi. (B) Table indicating the strains tested including Strain F (wild-type HSV-1) and different replicative-defective HSV-1 mutants and UV-irradiated (inactivated) HSV-1. (C) After gel scanning and densitometry quantitation, the results were expressed as the ratio of Arc protein levels in respect to total Actin. The results shown are representative of three independent experiments. ****p > 0.0001 (analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test).